ESR13 : Disruption of memory circuit function in epilepsy
M-GATE fellow: Wesley Clawson
Temporal Lobe Epilepsy is associated with cognitive deficits. The underlying mechanisms remain unknown. AMU is now routinely performing simultaneous recordings with high-density silicon probes in the nucleus reuniens, hippocampus and medium prefrontal cortex to study working memory in freely moving control rats. We will use the same approach in a TLE rat model. We will also record the entorhinal cortex-hippocampus-prefrontal cortex circuit. We will focus on neural codes and global dynamics. Specifically, we will use three key measures: sequence activation, inter-area coherence, and ability to plan future actions. We predict that a failure to encode/retrieve and/or build maps may explain cognitive deficits.
In collaboration with SISSA, INMED, UCL. SISSA will model the limited lesion of the hippocampus we make experimentally, and make predictions regarding alterations in neuronal dynamics. Predictions will be tested experimentally, via a constant feedback between experimental and theoretical approaches.
Clawson W, Vicente AF, Ferraris M, Bernard C, Battaglia D, Quilichini PP. Computing hubs in the hippocampus and cortex. Sci Adv. 2019 Jun 26;5(6):eaax4843. doi: 10.1126/sciadv.aax4843. eCollection 2019 Jun.