ESR15 : Circuits biomarkers for Alzheimer’s Disease

Supervisor: Dr. Pim Drinkenburg 

M-GATE fellow: Sean Tok

Alzheimer’s Disease manifests itself as is a disconnection syndrome caused by the disruption of white matter integrity, progressive loss of synapses and functional connectivity across different cortical and subcortical regions. Regions of the extended hippocampal formation such as the perirhinal cortex, the entorhinal cortex, and the hippocampus proper are among the first to be affected as the disease advances, and are critical for its debilitating cognitive symptoms. This project aims to determine whether pharmacological treatments may help rescue and/or restore functional synaptic connectivity and enhance putative compensatory mechanisms.

Preclinical rodent models that mimic aspects of the tau and/or amyloid pathology development as seen in AD, are open for advanced in vivo electrophysiological studies (e.g. hippocampal cortical connectivity and/or stimulation paradigms) into the neuronal circuits underlying the neurodegenerative pathology development and progression and the application of novel research tools (e.g. contribution) ATLAS. The project is closely linked to several other ESR’s, using potential biomarkers derived thereout.