ESR14 : Neural, Metabolic and biochemical mechanisms of epileptic seizure genesis and propagation


Supervisor Christophe Bernard, Institut de Neurosciences des Systèmes, Université d'Aix-Marseille, with Viktor Jirsa, in collaboration with UCL, RU, ATLAS. AMU has proposed a comprehensive mathematical framework that includes cellular and synaptic network variables to explain seizure dynamics. The model predicts that a state variable evolving slowly in time is required to explain seizure onset, time course and offset. Preliminary data show that molecular events such as those related to metabolism and energy supply, which evolve slowly in time, are integral components of this state variable. Alterations in molecular processes may also underlie cognitive deficits. We will combine molecular sensors and high-density electrophysiological recordings to obtain a complete electro-molecular picture of the events that may explain altered neuronal coding/retrieval, using computational frameworks such as reinforcement learning (in collaboration with UCL, DEEPMIND), and data analytical techniques for detecting molecular/neural patterns and sequences (in collaboration with RU), in particular for seizure prediction.

Relevant publications: Khodagholy et al., Nature Comm, 2013; Jirsa et al., Brain 2014.


Specific requirements and application procedure Good knowledge of MATLAB or similar computing software is required. Prior experience in in vivo intracellular electrophysiology is a plus. Candidates should apply by sending a CV, a brief outline of current research, scientific interests and career goals, as well as the name and contact details of at least two academic references to Dr. Christophe Bernard (christophe.bernard[!at!] as well to the MGATE management (info[!at!]